Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes
NR Collazo, LG Sultatos - Biochemical pharmacology, 1995 - Elsevier
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) can
be activated metabolically by cytochrome (s) P450 to DNA-damaging agents that result in …
be activated metabolically by cytochrome (s) P450 to DNA-damaging agents that result in …
Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue
K Doerr-O'Rourke, N Trushin, SS Hecht… - …, 1991 - academic.oup.com
The effect of phenethyl isothiocyanate (PEITC), a dietary inhibitor of carcinogenesis, on the
metabolism of the tobacco specific nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)-l …
metabolism of the tobacco specific nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)-l …
Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users
SS Hecht, SG Carmella, I Stepanov, J Jensen… - … Biomarkers & Prevention, 2008 - AACR
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is one of the most abundant carcinogens in smokeless tobacco products. NNK uptake …
(NNK) is one of the most abundant carcinogens in smokeless tobacco products. NNK uptake …
The profile of urinary metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats is determined by its pulmonary metabolism
T Schneider, E Frei, M Wiessler - Chemico-biological interactions, 1999 - Elsevier
Metabolism of the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) in rats was compared to metabolism in primary lung and liver cells …
butanone (NNK) in rats was compared to metabolism in primary lung and liver cells …
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in primary cultures of rat alveolar type II cells
E Schrader, KI Hirsch-Ernst, E Scholz, GF Kahl… - Drug metabolism and …, 2000 - ASPET
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
induces primarily lung tumors, which are assumed to derive from malignant transformation of …
induces primarily lung tumors, which are assumed to derive from malignant transformation of …
Modulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone demethylation and denitrosation by rat liver microsomes
A Castonguay, P Pepin, N Briere - Cancer letters, 1991 - Elsevier
The nicotine-derived N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone (NNK) is
abundant in tobacco smoke and is a potent carcinogen in laboratory animals. We have …
abundant in tobacco smoke and is a potent carcinogen in laboratory animals. We have …
Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes.
R Jorquera, A Castonguay, HM Schuller - Drug metabolism and disposition, 1992 - ASPET
The tobacco-specific N-nitrosamino 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is
a potent carcinogen in adult Syrian golden hamsters and causes a high incidence of tumors …
a potent carcinogen in adult Syrian golden hamsters and causes a high incidence of tumors …
Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the …
CL Zimmerman, Z Wu, P Upadhyaya… - …, 2004 - academic.oup.com
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is reduced to its main metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a reaction that is both stereoselective …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a reaction that is both stereoselective …
Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use
SS Hecht, SG Carmella, M Ye, K Le, JA Jensen… - Cancer research, 2002 - AACR
Two major metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanone (NNK) were previously shown to be highly persistent in human urine …
pyridyl)-1-butanone (NNK) were previously shown to be highly persistent in human urine …