Monocyte transmodulation: the next novel therapeutic approach in overcoming ischemic stroke?

J Park, JY Chang, JY Kim, JE Lee - Frontiers in neurology, 2020 - frontiersin.org
The immune response following neuroinflammation is a vital element of ischemic stroke
pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that …

Reparative system arising from CCR2 (+) monocyte conversion attenuates neuroinflammation following ischemic stroke

J Park, JY Kim, YR Kim, M Huang, JY Chang… - Translational Stroke …, 2021 - Springer
Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an
important immune response to wound healing and tissue repair. Mouse monocytes can be …

The role of monocytes in ischemic stroke pathobiology: new avenues to explore

A ElAli, N Jean LeBlanc - Frontiers in aging neuroscience, 2016 - frontiersin.org
Ischemic stroke accounts for the majority of stroke cases and constitutes a major cause of
death and disability in the industrialized world. Inflammation has been reported to constitute …

Macrophage and monocyte subsets in response to ischemic stroke

N Blank‐Stein, E Mass - European Journal of Immunology, 2023 - Wiley Online Library
Ischemic stroke is a leading cause of disability and mortality. Despite extensive efforts in
stroke research, the only pharmacological treatment currently available is arterial …

[HTML][HTML] Is immunomodulation a principal mechanism underlying how cell-based therapies enhance stroke recovery?

N Satani, SI Savitz - Neurotherapeutics, 2016 - Elsevier
Inflammation within the brain and in peripheral tissues contributes to brain injury following
ischemic stroke. Therapeutic modulation of the inflammatory response has been actively …

The translational potential of microglia and monocyte-derived macrophages in ischemic stroke

EE Wicks, KR Ran, JE Kim, R Xu, RP Lee… - Frontiers in …, 2022 - frontiersin.org
The immune response to ischemic stroke is an area of study that is at the forefront of stroke
research and presents promising new avenues for treatment development. Upon cerebral …

[HTML][HTML] Stem cell–based immunomodulation after stroke

MCS Boshuizen, GK Steinberg - Stroke, 2018 - journals.lww.com
Stroke is a major cause of death and disability worldwide. The inflammatory response is
pivotal to the pathophysiology of ischemic stroke. It begins in the vasculature directly after …

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

W Zhang, J Zhao, R Wang, M Jiang… - CNS neuroscience & …, 2019 - Wiley Online Library
Aims Blood‐borne monocytes/macrophages infiltrate the brain in massive numbers after
ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive …

The involvement and therapy target of immune cells after ischemic stroke

Z Jian, R Liu, X Zhu, D Smerin, Y Zhong, L Gu… - Frontiers in …, 2019 - frontiersin.org
After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

SE Lakhan, A Kirchgessner, M Hofer - Journal of translational medicine, 2009 - Springer
Acute ischemic stroke is the third leading cause of death in industrialized countries and the
most frequent cause of permanent disability in adults worldwide. Despite advances in the …