[HTML][HTML] A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer
J Calbo, E van Montfort, N Proost, E van Drunen… - Cancer cell, 2011 - cell.com
Small cell lung cancer (SCLC) is the lung neoplasia with the poorest prognosis, due to its
high metastatic potential and chemoresistance upon relapse. Using the previously …
high metastatic potential and chemoresistance upon relapse. Using the previously …
[HTML][HTML] Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models
Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A
major difference between SCLC and other forms of lung cancer is that SCLC tumors often …
major difference between SCLC and other forms of lung cancer is that SCLC tumors often …
Characterization of the cell of origin for small cell lung cancer
KS Park, MC Liang, DM Raiser, R Zamponi, RR Roach… - Cell cycle, 2011 - Taylor & Francis
Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects
more than 200,000 people worldwide every year with a very high mortality rate. Here, we …
more than 200,000 people worldwide every year with a very high mortality rate. Here, we …
[HTML][HTML] Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes
W Zhang, L Girard, YA Zhang, T Haruki… - … lung cancer research, 2018 - ncbi.nlm.nih.gov
Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …
Novel hybrid phenotype revealed in small cell lung cancer by a transcription factor network model that can explain tumor heterogeneity
Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early
invasion and refractory relapse after initial treatment response. Although these aggressive …
invasion and refractory relapse after initial treatment response. Although these aggressive …
[HTML][HTML] Molecular profiles of small cell lung cancer subtypes: therapeutic implications
A Schwendenwein, Z Megyesfalvi, N Barany… - Molecular Therapy …, 2021 - cell.com
Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers)
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
is an exceptionally lethal malignancy characterized by rapid doubling time and high …
[HTML][HTML] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …
[HTML][HTML] Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT …
A Krohn, T Ahrens, A Yalcin, T Plönes, J Wehrle… - PloS one, 2014 - journals.plos.org
Small Cell Lung Cancer (SCLC) is a specific subtype of lung cancer presenting as highly
metastatic disease with extremely poor prognosis. Despite responding initially well to chemo …
metastatic disease with extremely poor prognosis. Despite responding initially well to chemo …
[HTML][HTML] Identification and targeting of long-term tumor-propagating cells in small cell lung cancer
NS Jahchan, JS Lim, B Bola, K Morris, G Seitz, KQ Tran… - Cell reports, 2016 - cell.com
Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast
growth, early dissemination, and rapid resistance to chemotherapy. We identified a …
growth, early dissemination, and rapid resistance to chemotherapy. We identified a …
Small cell lung cancer: will recent progress lead to improved outcomes?
Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy with a unique
natural history characterized by a short doubling time, high growth fraction, and early …
natural history characterized by a short doubling time, high growth fraction, and early …