Cytokines such as IL-1 and TNF are primarily pro-inflammatory. The inflammation induced
by these cytokines is reflected in the type of genes they induce. In the pathogenesis of …

Inflammatory conditions in some tissues increase the risk of cancer. Cytokines and
chemokines are components of an intensive dialog promoting angiogenesis, metastasis …

[Frontiers in Bioscience S2, 176-183, January 1, 2010] 176 Roles of inflammation in cancer
initiation, progression, and metastas Page 1 [Frontiers in Bioscience S2, 176-183, January 1 …

The mixture of cytokines that is produced in the tumour microenvironment has an important
role in cancer pathogenesis. Cytokines that are released in response to infection …

Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

An inflammatory component is present in the microenvironment of most neoplastic tissues,
including those not causally related to an obvious inflammatory process. Epidemiological …

A new paradigm is becoming widely accepted, that chronic inflammation, driven in part by
chemokines and cytokines at the site of a tumour, may facilitate tumour progression instead …

The concept that the immune system recognizes and controls cancer was first postulated
over a century ago, and cancer immunity has continued to be vigorously debated and …

The epithelial tumour microenvironment is a complex tissue comprising variable numbers of
tumour cells, fibroblasts, endothelial cells and infiltrating leucocytes. Cytokines are key …

Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …