Glial cells and chronic pain
RD Gosselin, MR Suter, RR Ji… - The …, 2010 - journals.sagepub.com
Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …
promising target against pathological pain. Indeed, changes in glial phenotypes have been …
Spinal astrocytes as therapeutic targets for pathological pain
T Nakagawa, S Kaneko - Journal of pharmacological sciences, 2010 - jstage.jst.go.jp
Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …
[HTML][HTML] Targeting astrocyte signaling for chronic pain
Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …
Glial activation and pathological pain
J Wieseler-Frank, SF Maier, LR Watkins - Neurochemistry international, 2004 - Elsevier
Pain is a sensation we have all experienced. For most of us, the pain has been temporary.
However, for patients with pathological pain, the pain experience is unending, with little …
However, for patients with pathological pain, the pain experience is unending, with little …
Do glial cells control pain?
Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …
The role of glia and the immune system in the development and maintenance of neuropathic pain
Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …
pathophysiologic mechanisms and origins. Recent studies indicate a communication …
Reactive astrocytes: critical players in the development of chronic pain
J Tang, M Bair, G Descalzi - Frontiers in psychiatry, 2021 - frontiersin.org
Chronic pain is associated with long term plasticity of nociceptive pathways in the central
nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence …
nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence …
Modulating the delicate glial–neuronal interactions in neuropathic pain: promises and potential caveats
V Tiwari, Y Guan, SN Raja - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …
initiate a series of signaling cascades that modulate pain processing at both spinal and …
Spinal glial activation contributes to pathological pain states
H Cao, YQ Zhang - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …
study on the neuronal processing of pain, mechanisms underlying the creation and …
The role of glia in the spinal cord in neuropathic and inflammatory pain
EA Old, AK Clark, M Malcangio - Pain control, 2015 - Springer
Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the
pain experience persists after the painful stimulus has resolved. The efficacy of current …
pain experience persists after the painful stimulus has resolved. The efficacy of current …