Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …

Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …

Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …

Pain is a sensation we have all experienced. For most of us, the pain has been temporary.
However, for patients with pathological pain, the pain experience is unending, with little …

Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Chronic pain is associated with long term plasticity of nociceptive pathways in the central
nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence …

During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the
pain experience persists after the painful stimulus has resolved. The efficacy of current …