The emerging literature implicates a role for glia/cytokines in persistent pain. However, the
mechanisms by which these non-neural elements contribute to CNS activity-dependent …

Contemporary studies illustrate that peripheral injuries activate glial components of the
peripheral and central cellular circuitry. The subsequent release of glial stressors or …

A remarkable series of findings over the last decade or so has demonstrated a previously
unrecognized role for CNS glia in many aspects of neuronal functioning including pain …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Peripheral tissue injury/inflammation can alter the properties of somatic sensory pathways,
resulting in behavioral hypersensitivity and pathological and/or chronic pain, including …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …

When you hurt yourself, you become consciously aware of the pain because a chain of
neurons carries the pain message from the injury to the spinal cord, and then from the spinal …

While glial activation is an integral part of pain pathogenesis, the existence of a causal
relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …