Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant
Background Lipids serve as multifunctional metabolites that have important implications for
the pregnant mother and developing fetus. Abnormalities in lipids have emerged as …
the pregnant mother and developing fetus. Abnormalities in lipids have emerged as …
Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to
characterize maternal lipidomic signatures associated with preterm birth and neonatal …
characterize maternal lipidomic signatures associated with preterm birth and neonatal …
Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study
L Chen, SA Mir, AK Bendt, EWL Chua, K Narasimhan… - BMC medicine, 2023 - Springer
Background Adaptations in lipid metabolism are essential to meet the physiological
demands of pregnancy and any aberration may result in adverse outcomes for both mother …
demands of pregnancy and any aberration may result in adverse outcomes for both mother …
Lipidomics reveals elevated plasmalogens in women with obesity who develop preeclampsia
Objective: Preeclampsia (PE) is a prevalent pregnancy disorder worldwide with limited
preventative treatments available. Obesity triples the risk for PE, yet only 10% of women with …
preventative treatments available. Obesity triples the risk for PE, yet only 10% of women with …
[HTML][HTML] LC-MS/MS based untargeted lipidomics uncovers lipid signatures of late-onset preeclampsia
Y Yang, L Wu, Y Lv, Z Miao, Y Wang, J Yan, J Li, C Li… - Biochimie, 2023 - Elsevier
The mechanisms underlying late-onset preeclampsia (LOPE) remain unknown. Metabolic
disturbances have been implicated as a primary factor in LOPE development. Lipids have …
disturbances have been implicated as a primary factor in LOPE development. Lipids have …
Longitudinal lipidomic profiles during pregnancy and associations with neonatal anthropometry: findings from a multiracial cohort
Background Maternal lipidomic profiling offers promise for characterizing lipid metabolites
during pregnancy, but longitudinal data are limited. This study aimed to examine …
during pregnancy, but longitudinal data are limited. This study aimed to examine …
The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and
proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are …
proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are …
Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis
Background Preeclampsia is a complication during pregnancy characterised by new-onset
hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in …
hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in …
Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia
SM Lee, JY Moon, BY Lim, SM Kim, CW Park… - Scientific Reports, 2019 - nature.com
Preeclampsia is one of the most serious complications during pregnancy, defined as
development of hypertension during late pregnancy affecting other organ systems …
development of hypertension during late pregnancy affecting other organ systems …
Detection and confirmation of serum lipid biomarkers for preeclampsia using direct infusion mass spectrometry [S]
S Anand, S Young, MS Esplin, B Peaden… - Journal of lipid …, 2016 - ASBMB
Despite substantial research, the early diagnosis of preeclampsia remains elusive. Lipids
are now recognized to be involved in regulation and pathophysiology of some disease …
are now recognized to be involved in regulation and pathophysiology of some disease …