Sirtuins are a family of enzymes, which govern a number of cellular processes essential for
maintaining physiological balance. SIRT6, a nuclear sirtuin, is implicated in the development …

Cardiac hypertrophy is a multifactorial disease characterized by multiple molecular
alterations. One of these alterations is change in the activity of Akt, which plays a central role …

Pathological myocardial remodelling is the initial factor of chronic heart failure (CHF) and is
induced by multiple factors. We previously demonstrated that histone acetylation is involved …

Cardiac hypertrophy is an adaptive response to pressure, volume stress, and loss of
contractile mass from prior infarction. Metabolic changes in cardiac hypertrophy include …

Aim The transcriptional cofactor receptor‐interacting protein 140 (RIP 140) is known as a
deleterious regulator of cardiac mitochondrial function and energy metabolic homeostasis …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

Sirtuin-3 (Sirt3) is a major mitochondrial deacetylase enzyme that regulates multiple
metabolic pathways, and its expression is decreased in diabetes type 1 and type 2 diabetes …

Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many
organisms. Increased expression of SIRT3 has been linked to an extended life span in …

Angiotensin II (AngII) induces the development of vascular hypertrophy and hypertension.
We have shown previously that overexpression of class III deacetylase SIRT1 inhibits AngII …

SIRT1 is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, which
removes acetyl groups from many target proteins, such as histone proteins, transcription …