Neuronal excitation increases extracellular K+ concentration ([K+] o) in vivo and in
incubated brain tissue by stimulation of postsynaptic glutamatergic receptors and by channel …

This paper describes the roles of the astrocytic Na+, K+-ATPase for K+ homeostasis in brain.
After neuronal excitation it alone mediates initial cellular re-accumulation of moderately …

The importance of astrocytic K+ uptake for extracellular K+([K+] e) clearance during
neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It …

An important feature of neuronal signalling is the increased concentration of K+ in the
extracellular space. The K+ concentration is restored to its original basal level primarily by …

Publisher Summary This chapter presents certain arguments in favor of an active uptake of
K+ in exchange for Na+ mediated by the glial Na+, K+-ATPase by comparing results …

Key points Management of glutamate and K+ in brain extracellular space is of critical
importance to neuronal function. The astrocytic α2β2 Na+/K+‐ATPase isoform combination …

Membrane depolarization by elevated extracellular K+ concentration ([K+] o) causes rapid
Na+ influx through voltage-sensitive Na+ channels into excitable cells. The consequent …

Initial clearance of extracellular K+([K+] o) following neuronal excitation occurs by astrocytic
uptake, because elevated [K+] o activates astrocytic but not neuronal Na+, K+-ATPases …

There is disagreement in the literature whether or not deoxyglucose accumulation, a
measure of glycolytic activity, is increased in astrocytes during exposure to elevated …

Recent advances in brain energy metabolism support the notion that glycogen in astrocytes
is necessary for the clearance of neuronally-released K+ from the extracellular space …