Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific
CD4+ T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-γ) …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

One striking clinical feature of hepatitis C virus (HCV) infection is that more than 50% of
patients with acute hepatitis C will develop chronic infection. To investigate its possible …

Background & Aims: The prospective comparison of patients with acute hepatitis C virus
(HCV) who spontaneously clear the virus with those who cannot achieve viral elimination …

Abstract The CD4+ CD25+ regulatory T lymphocytes have been implicated in suppressing T
cell immune responses. Our aim was to characterize the frequency, phenotype, function, and …

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the …

Background & Aims: The role of virus-specific T-helper lymphocyte reactivity in determining
the therapeutic response in chronic hepatitis C virus (HCV) infection is not fully understood …

Regulatory T (TR) cells consist of phenotypically and functionally distinct CD4+ and CD8+ T
cell subsets engaged both in maintaining self-tolerance and in preventing anti–non-self …

The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)‐
specific CD8+ T cells to control the virus during persistent infection have not been fully …

BACKGROUND: The outcome of acute hepatitis C is determined by early host–virus
interactions, particularly involving the antiviral T-cell response. OBJECTIVES: To identify …