The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)‐
specific CD8+ T cells to control the virus during persistent infection have not been fully …

Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing
so, the virus evades host adaptive immune responses, although the mechanisms …

Background/Aims: The intrahepatic immune system is likely to play a key role in determining
the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is …

Hepatitis C virus (HCV) infection is a major cause of liver damage, with virus-induced end-
stage disease such as liver cirrhosis and hepatocellular carcinoma resulting in a high rate of …

Summary CD4+ CD25+ T regulatory cells may play a role in the different clinical
presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell …

Cellular immune responses are likely to play a key role in determining the clinical outcome
in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their …

The cellular immune response contributes to clearance of hepatitis C virus (HCV) and
persists for decades after recovery from infection. The immunological basis for the …

Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, affecting approximately 2%
of the world'population. The immune mechanisms responsible for the highly variable natural …

Background and aims: Cellular mediated immunity (CMI) is thought to play a key role in
resolution of primary hepatitis C virus (HCV) infection. However, CD4+ and CD8+ T cell …

Background: To assess the role played by the immune response in the outcome of hepatitis
C virus infection, the CD4+ T-lymphocyte response to viral antigens was studied in infected …