Reactive oxygen species (ROS) are best known for being involved in cellular metabolism
and oxidative stress, but also play important roles in cell communication. ROS signaling has …

The process of cell differentiation goes hand‐in‐hand with metabolic adaptations, which are
needed to provide energy and new metabolites. Carbon monoxide (CO) is an endogenous …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …

Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide
(CO) and iron into circulation. These byproducts of heme degradation can have potent …

To examine the role of carbon monoxide (CO) as a putative neuronal messenger and
regulator of cGMP level in vivo, we exploited an animal model to increase brain capability to …

Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Carbon monoxide is produced endogenously in humans through the breakdown of
hemoglobin by heme oxygenase. Although originally thought to be a superfluous by-product …

Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …

The highly toxic gas carbon monoxide (CO) displays many physiological roles in several
organs and tissues. Although many diseases, including cancer, hematological diseases …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra pars compacta (SNpc) accompanied by increased oxidative damage …