Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-
related death necessitates better understanding of the early viral dynamics, host responses …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in
the global coronavirus disease 2019 (COVID-19) pandemic. Despite several single-cell …

Despite extensive analyses, there remains an urgent need to delineate immune cell states
that contribute to mortality in people critically ill with COVID-19. Here, we present high …

The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical
characteristics with other acute viral infections. We studied the whole-blood transcriptomic …

There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …

Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19)
pathogenesis and immune response is vital for developing therapies. Single-cell RNA …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health threat …

The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the
cellular disease dynamics remains limited. In our unique COVID-19 human challenge study …

COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes
pandemic control and strategy difficult; optimizing management requires a systems biology …

The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in
excess morbidity and mortality as well as economic decline. To characterise the systemic …