Acute tubular necrosis causes a loss of renal function, which clinically presents as acute
kidney failure (AKI). The biochemical signaling pathways that trigger necrosis have been …

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered
when an organ undergoes a transient reduction or cessation of blood flow, followed by re …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Ischemic acute kidney injury (AKI) is a frequent complication resulting from a myriad of
conditions that decrease effective arterial blood volume to the kidneys including myocardial …

Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

The term acute tubular necrosis was thought to represent a misnomer derived from
morphological studies of human necropsies and necrosis was thought to represent an …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Acute kidney injury (AKI) is a common clinical entity associated with high morbidity and
mortality and clinical costs. The pathophysiology is multifaceted and involves inflammation …