BACKGROUND AND PURPOSE The glucagon‐like peptides GLP‐1 and GLP‐2 are
secreted from enteroendocrine L‐cells following nutrient ingestion. Drugs that increase …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

During the last decades it has become clear that bile acids not only act as simple fat
solubilizers, but additionally represent complex hormonal metabolic integrators. Bile acids …

Background and Purpose Nutrient sensing in the gut is believed to be accomplished through
activation of GPCR s expressed on enteroendocrine cells. In particular, L‐cells located …

Bile acids play essential roles in the absorption of dietary lipids and in the regulation of bile
acid biosynthesis. Recently, a G protein-coupled receptor, TGR5, was identified as a cell …

Objective Recent preclinical work has suggested that postprandial flow of bile acids into the
small intestine potentiates nutrient-induced glucagon-like peptide 1 (GLP1) secretion via …

Bile acid sequestrants have been used for decades for the treatment of
hypercholesterolaemia. Sequestering of bile acids in the intestinal lumen interrupts …

BACKGROUND & AIMS: The mechanisms by which reflux of bile acids into the pancreas
induces pancreatitis are unknown. We reasoned that key events responsible for this …

Abstract Objective Glucagon-like peptides (GLPs) are secreted from enteroendocrine cells in
response to nutrients and bile acids and control metabolism via actions on structurally …

Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response to a range of
nutrients, hormones, and neurotransmitters. Its potency as an insulin secretagogue has led …