Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

The public health burden of Alzheimer disease (AD), the most common neurodegenerative
disease, threatens to explode in the middle of this century. Current FDA-approved AD …

For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …

Sphingolipids in the membranes of neurons play important roles in signal transduction,
either by modulating the localization and activation of membrane-associated receptors or by …

Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Although the brain contains a high content of sphingolipids, we know relatively little about
the roles that sphingolipids play in regulating neural functions. Once regarded only for their …

Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Alzheimer's disease is characterized by the progressive accumulation of extracellular
deposits of the amyloid β-peptide (Aβ) and intraneuronal aggregates of the microtubule …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as
signaling molecules for regulating a diverse range of cellular processes, including cell …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is
associated with several pathophysiological features, including cellular dysfunction, failure of …