Sphingolipids in Alzheimer's disease, how can we target them?
SM Crivelli, C Giovagnoni, L Visseren… - Advanced drug delivery …, 2020 - Elsevier
Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …
downstream effects on neuronal homeostasis and the immune system, provide a framework …
Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
MM Mielke, CG Lyketsos - Neuromolecular medicine, 2010 - Springer
The public health burden of Alzheimer disease (AD), the most common neurodegenerative
disease, threatens to explode in the middle of this century. Current FDA-approved AD …
disease, threatens to explode in the middle of this century. Current FDA-approved AD …
Sphingolipids in neurodegeneration (with focus on ceramide and S1P)
G Wang, E Bieberich - Advances in biological regulation, 2018 - Elsevier
For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
NJ Haughey, VVR Bandaru, M Bae… - Biochimica et Biophysica …, 2010 - Elsevier
Sphingolipids in the membranes of neurons play important roles in signal transduction,
either by modulating the localization and activation of membrane-associated receptors or by …
either by modulating the localization and activation of membrane-associated receptors or by …
[HTML][HTML] The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
Sphingolipids in neurodegeneration
NJ Haughey - Neuromolecular medicine, 2010 - Springer
Although the brain contains a high content of sphingolipids, we know relatively little about
the roles that sphingolipids play in regulating neural functions. Once regarded only for their …
the roles that sphingolipids play in regulating neural functions. Once regarded only for their …
Sphingolipid control of cognitive functions in health and disease
LS Kalinichenko, E Gulbins, J Kornhuber… - Progress in Lipid …, 2022 - Elsevier
Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …
mediating the successful adaptation of individuals to constantly changing environmental …
Sphingolipids: critical players in Alzheimer's disease
G van Echten-Deckert, J Walter - Progress in lipid research, 2012 - Elsevier
Alzheimer's disease is characterized by the progressive accumulation of extracellular
deposits of the amyloid β-peptide (Aβ) and intraneuronal aggregates of the microtubule …
deposits of the amyloid β-peptide (Aβ) and intraneuronal aggregates of the microtubule …
[HTML][HTML] Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy
JY Lee, HK Jin, J Bae - BMB reports, 2020 - ncbi.nlm.nih.gov
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as
signaling molecules for regulating a diverse range of cellular processes, including cell …
signaling molecules for regulating a diverse range of cellular processes, including cell …
[HTML][HTML] Diverse roles of ceramide in the progression and pathogenesis of Alzheimer's disease
MR Chowdhury, HK Jin, J Bae - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is
associated with several pathophysiological features, including cellular dysfunction, failure of …
associated with several pathophysiological features, including cellular dysfunction, failure of …