Genetic basis of human congenital heart disease

SN Nees, WK Chung - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …

Molecular mechanisms of congenital heart disease

H Jing-bin, L Ying-long, S Pei-wu, L Xiao-dong… - Cardiovascular …, 2010 - Elsevier
BACKGROUND: Congenital heart disease (CHD) is the most common type of birth defect.
Despite the many advances in our understanding of cardiac development and many genes …

Genetics and genomics of congenital heart disease

S Zaidi, M Brueckner - Circulation research, 2017 - Am Heart Assoc
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Molecular genetic mechanisms of congenital heart disease

TZ Choudhury, V Garg - Current opinion in genetics & development, 2022 - Elsevier
Congenital heart disease (CHD) affects~ 1% of all live births, but a definitive etiology is
identified in only~ 50%. The causes include chromosomal aneuploidies and copy-number …

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

AV Postma, CR Bezzina, VM Christoffels - Journal of human genetics, 2016 - nature.com
Congenital heart disease (CHD) is the most common type of birth defect. The advent of
corrective cardiac surgery and the increase in knowledge concerning the longitudinal care …

The molecular basis of congenital heart disease

ME Mitchell, TL Sander, DB Klinkner… - Seminars in thoracic and …, 2007 - Elsevier
Clinically relevant congenital heart disease affects 1% of all live births. It is the leading
cause of birth defects–related death in the United States, claiming more than 6000 lives per …

Toward a molecular understanding of congenital heart disease

RM Payne, MC Johnson, JW Grant, AW Strauss - Circulation, 1995 - Am Heart Assoc
Background This review discusses the incidence and importance of congenital heart
disease (CHD), the reasons that investigation of causative mechanisms for human CHD has …

The molecular genetics of congenital heart disease: a review of recent developments

M Wolf, CT Basson - Current Opinion in Cardiology, 2010 - journals.lww.com
The recent developments in the genetics of congenital heart disease are reviewed. In many
cases, it is the novel interactions of previously known genes that highlight this year's …

Genetics of congenital heart disease

JJ Edwards, BD Gelb - Current opinion in cardiology, 2016 - journals.lww.com
Recent technological advances have rapidly expanded our understanding of CHD genetics,
and support the applicability to the clinical domain in both sporadic and inherited disease …

Molecular genetics and complex inheritance of congenital heart disease

NS Diab, S Barish, W Dong, S Zhao, G Allington, X Yu… - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …