Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …

Two-dimensional (2D) cell cultures have been the standard for many different applications,
ranging from basic research to stem cell and cancer research to regenerative medicine, for …

It is recognized that tumors do not exist and grow as isolated entities of neoplastic cells, but
rather in continuous and bidirectional communication with adjacent stromal cells. Stromal …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

In recent years, evidence has indicated that the tumor microenvironment (TME) plays a
significant role in tumor progression. Fibroblasts represent an abundant cell population in …