Some countries have introduced mandatory folic acid fortification, whereas others support
periconceptional supplementation of women in childbearing age. Several European …

Promotion of folic acid to prevent neural Tube Defects (NTD) has been ongoing for ten years
in Ireland, without a concomitant reduction in the total birth prevalence of NTD. The …

Neural tube defects (NTD) are common congenital malformations leading to severe
disability or even death. The causes of NTD are multifactorial, including genetic …

Background Periconceptional use of vitamin supplements containing folic acid reduces the
risk of a neural tube defect (NTD). In November 1998, food fortification with folic acid was …

Objective In 1991, the Medical Research Council (MRC) Vitamin Study demonstrated that
folic acid taken before pregnancy and in early pregnancy reduced the risk of a neural tube …

Objectives: We conducted a case‐control study to investigate the effectiveness of efforts to
increase folate intake in Western Australia (WA) for the prevention of neural tube defects …

Abstract Background/Aims: To review the main results of intervention trials which showed
the efficacy of periconceptional folic acid-containing multivitamin and folic acid …

Background In 1993 all women of childbearing age in the Netherlands were advised to take
a daily 0.5 mg folic acid pill to reduce the risk for neural tube defects. This study describes …

Each year, more than 4500 pregnancies in the European Union are affected by neural tube
defects (NTD). Unambiguous evidence of the effectiveness of periconceptional folic acid in …

A working group was established to evaluate the need for an increased folate intake in
Danish women to decrease the risk of neural tube defects (NTDs). NTD are birth defects …