PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning

MM Mocanu, RM Bell, DM Yellon - Journal of molecular and cellular …, 2002 - Elsevier
MM Mocanu, RM Bell and DM Yellon. PI3 Kinase and not p42/p44 Appears to be Implicated
in the Protection Conferred by Ischemic Preconditioning. Journal of Molecular and Cellular …

Ischaemic preconditioning is not mediated by oxygen derived free radicals in rats

V Richard, C Tron, C Thuillez - Cardiovascular research, 1993 - academic.oup.com
Objective: Although several studies have shown that ischaemic preconditioning greatly limits
myocardial infarct size in the rat, the mechanisms of the beneficial effect of preconditioning …

Sex is no determinant of cardioprotection by ischemic preconditioning in rats, but ischemic/reperfused tissue mass is for remote ischemic preconditioning

HR Lieder, A Irmert, M Kamler, G Heusch… - Physiological …, 2019 - Wiley Online Library
We determined the impact of sex on the magnitude of cardioprotection by local and remote
ischemic preconditioning (IPC and RIPC) and of ischemic/reperfused peripheral tissue mass …

Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption

X Zhu, B Liu, S Zhou, YR Chen… - American Journal …, 2007 - journals.physiology.org
Ischemic preconditioning (IPC) strongly protects against ischemia-reperfusion injury;
however, its effect on subsequent myocardial oxygenation is unknown. Therefore, we …

Aging mouse hearts are refractory to infarct size reduction with post-conditioning

K Przyklenk, M Maynard, CE Darling… - Journal of the American …, 2008 - jacc.org
Objectives: Our aim was to establish whether the efficacy of post-conditioning is maintained
in aging hearts. Background: Post-conditioning, or relief of myocardial ischemia in a …

Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes

K Przyklenk, M Maynard, DL Greiner… - Antioxidants & redox …, 2011 - liebertpub.com
Postconditioning (PostC), or relief of myocardial ischemia in a stuttered manner, has been
shown to reduce infarct size, due in part to upregulation of survival kinase signaling. Virtually …

Reduction of myocardial ischemia-reperfusion injury with pre-and postconditioning: molecular mechanisms and therapeutic targets

MM Galagudza, IO Blokhin, AA Shmonin… - … Current Drug Targets …, 2008 - ingentaconnect.com
Reduction of infarct size as well as alleviation of other ischemia-and reperfusion-associated
injuries are the goals of primary importance in cardiology. One of the remedies is considered …

Role of reactive oxygen species in ischemic preconditioning of subcellular organelles in the heart

HK Saini, J Machackova, NS Dhalla - Antioxidants and Redox …, 2004 - liebertpub.com
Ischemic preconditioning (IPC) is an endogenous adaptive mechanism and is manifested by
early and delayed phases of cardioprotection. Brief episodes of ischemia-reperfusion during …

Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities

S Pons, V Martin, L Portal, R Zini, D Morin… - Journal of molecular and …, 2013 - Elsevier
Obesity is a major health issue that impedes the ability of preconditioning and
postconditioning to protect the myocardium against infarction secondary to dysregulation of …

Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury

D Schulman, DS Latchman… - American Journal of …, 2001 - journals.physiology.org
Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on
aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle …