Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …

Results Forty-two of fifty-five subjects enrolled had complete sampling. Volume of
distribution (median= 0.38 L/kg, intraquartile range= 0.20 L/kg) and elimination rate …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …

Standard doses of piperacillin/tazobactam (9–13.5 g over 24 h) administered by continuous
infusion (CI) routinely provide serum concentrations in excess of the susceptibility …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Objective To determine whether established ceftolozane/tazobactam (C/T) dosing is
adequate for patients with augmented renal clearance (ARC) and bacterial infection …

In this study, a pharmacokinetic-pharmacodynamic (PK-PD) target attainment analysis of
imipenem (IPM) in patients with impaired renal function was conducted. IPM (500mg) was …

The study aimed to evaluate saturation of piperacillin elimination in critically ill adult patients.
Seventeen critically ill adult patients received continuous and intermittent infusion of …

(1) Background: Piperacillin-tazobactam represents the first-line option for treating infections
caused by full-or multi-susceptible Enterobacterales and/or Pseudomonas aeruginosa in …