Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …

The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients
with microbiologically documented infections is currently unknown. We conducted a …

Objective The purpose of this study is to evaluate the outcome differences between patients
receiving piperacillin-tazobactam pre-and post-implementation of an extended infusion …

The introduction of a new protocol at Ghent University Hospital (Ghent, Belgium) for the
extended administration of piperacillin-tazobactam (TZP) and meropenem drew attention to …

Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

Background: In the era of escalating antimicrobial resistance, the choice of effective empiric
antimicrobial therapy has become considerably more difficult. In an attempt to improve …

BACKGROUND: Use of extended infusions of piperacillin/tazobactam (PT) in adult patients
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

Tazobactam is a new derivative of penicillinic acid sulfone, which functions as an
irreversible inhibitor of many β‐lactamases. The disposition of tazobactam M1 metabolite …

Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …