Large-scale genotyping by mass spectrometry: experience, advances and obstacles

D Lechner, GM Lathrop, IG Gut - Current opinion in chemical biology, 2002 - Elsevier
Single nucleotide polymorphism (SNP) genotyping has become a key technology for genetic
studies. In recent years, matrix-assisted laser desorption/ionization (MALDI) time-of-flight …

Genotyping single-nucleotide polymorphisms by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry

S Sauer, IG Gut - Journal of Chromatography B, 2002 - Elsevier
In recent years matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI) has emerged as a very powerful method for genotyping single nucleotide …

Single-nucleotide polymorphism analysis by MALDI–TOF mass spectrometry

TJ Griffin, LM Smith - Trends in biotechnology, 2000 - cell.com
Single-nucleotide polymorphisms (SNPs) have great potential for use in genetic-mapping
studies, which locate and characterize genes that are important in human disease and …

MALDI-TOF MS: a platform technology for genetic discovery

D van den Boom, M Beaulieu, P Oeth, R Roth… - International Journal of …, 2004 - Elsevier
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has been applied as a high-throughput platform technology for qualitative and …

Single-nucleotide polymorphisms: analysis by mass spectrometry

S Sauer, R Reinhardt, H Lehrach, IG Gut - Nature protocols, 2006 - nature.com
Matrix-assisted laser desorption-ionization (MALDI) mass spectrometry has evolved as a
powerful method for analyzing nucleic acids. Here we provide protocols for genotyping …

Single nucleotide polymorphism analyses by MALDI-TOF MS

K Tang, D Opalsky, K Abel, D van den Boom… - International Journal of …, 2003 - Elsevier
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has been used to detect single nucleotide polymorphisms (SNPs). Methods of …

Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry …

P Oeth, G Mistro, G Marnellos, T Shi… - … : Methods and Protocols, 2009 - Springer
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has developed over the past decade into a versatile tool for the analysis of nucleic …

High‐throughput multiplex SNP genotyping with MALDI‐TOF mass spectrometry: practice, problems and promise

MS Bray, E Boerwinkle, PA Doris - Human mutation, 2001 - Wiley Online Library
Single nucleotide polymorphisms (SNPs) are currently being identified and mapped at a
remarkable pace, providing a rich genetic resource with vast potential for disease gene …

Quantitative approach to single-nucleotide polymorphism analysis using MALDI-TOF mass spectrometry

P Ross, L Hall, LA Haff - Biotechniques, 2000 - Taylor & Francis
Pooling of DNA samples before genotyping is a valuable means of streamlining large-scale
genotyping efforts in disease association studies, single-nucleotide polymorphism (SNP) …

Multiplex single-nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

H Yang, H Wang, J Wang, Y Cai, G Zhou, FC He… - Analytical …, 2003 - Elsevier
A robust high-throughput single-nucleotide polymorphism (SNP) genotyping method is
reported, which applies allele-specific extension to achieve allelic discrimination and uses …