Oxytocin and anxiety disorders

MG Gottschalk, K Domschke - Behavioral Pharmacology of Neuropeptides …, 2018 - Springer
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research
in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias …

A precision medicine approach to oxytocin trials

E Andari, R Hurlemann, LJ Young - Behavioral Pharmacology of …, 2018 - Springer
In this chapter, we introduce a new area of social pharmacology that encompasses the study
of the role of neuromodulators in modulating a wide range of social behaviors and brain …

Oxytocin׳ s role in anxiety: A critical appraisal

K MacDonald, D Feifel - Brain research, 2014 - Elsevier
A growing literature suggests that the oxytocin (OT) system may play a role in human anxiety
states, anxiety-related traits, and moreover, that this system may be a target for the …

Overview of human oxytocin research

KM Kendrick, AJ Guastella, B Becker - Behavioral pharmacology of …, 2018 - Springer
Social dysfunction is a core symptom of many psychiatric disorders and current medications
have little or no remedial effects on this. Following on from extensive studies on animal …

[HTML][HTML] Oxytocin in general anxiety and social fear: a translational approach

ID Neumann, DA Slattery - Biological psychiatry, 2016 - Elsevier
The neuropeptide oxytocin (OXT) has been revealed as a profound anxiolytic and antistress
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …

A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function

H Tost, B Kolachana, S Hakimi… - Proceedings of the …, 2010 - National Acad Sciences
The evolutionarily highly conserved neuropeptide oxytocin is a key mediator of social and
emotional behavior in mammals, including humans. A common variant (rs53576) in the …

Oxytocin and social functioning

C Jones, I Barrera, S Brothers, R Ring… - Dialogues in clinical …, 2017 - Taylor & Francis
Social anxiety is a form of anxiety characterized by continuous fear of one or more social or
performance situations. Although multiple treatment modalities (cognitive behavioral …

Oxytocin promotes accurate fear discrimination and adaptive defensive behaviors

V Olivera-Pasilio, J Dabrowska - Frontiers in Neuroscience, 2020 - frontiersin.org
The nonapeptide, oxytocin (OT), known for its role in social bonding and attachment
formation, has demonstrated anxiolytic properties in animal models and human studies …

Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children

DS Carson, SW Berquist, TH Trujillo, JP Garner… - Molecular …, 2015 - nature.com
The neuropeptide oxytocin (OXT) exerts anxiolytic and prosocial effects in the central
nervous system of rodents. A number of recent studies have attempted to translate these …

Oxytocin and emotion processing

M Di Simplicio, CJ Harmer - Journal of Psychopharmacology, 2016 - journals.sagepub.com
Since the observation that oxytocin has key effects on social decision making, research on
this exciting neuropeptide has doubled in volume: hundreds of studies have pursued the …