[HTML][HTML] P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition
W Xia, J Zhuang, G Wang, J Ni, J Wang, Y Ye - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract P4HB and GRP78 are molecular chaperones involved in cellular response to ER
stress. They have been linked to cancer progression; however, their roles in hepatocellular …
stress. They have been linked to cancer progression; however, their roles in hepatocellular …
Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis
H You, N Zhang, T Yu, L Ma, Q Li, X Wang… - British Journal of …, 2023 - nature.com
Background GRP78 has been implicated in hepatocarcinogenesis. However, the clinical
relevance, biological functions and related regulatory mechanisms of GRP78 in hepatitis B …
relevance, biological functions and related regulatory mechanisms of GRP78 in hepatitis B …
GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6
H Xiong, H Xiao, C Luo, L Chen, X Liu, Z Hu… - Experimental Cell …, 2019 - Elsevier
Recent studies have shown that the expression levels of glucose-regulated protein 78
(GRP78) and homeobox B9 (HOXB9) are both upregulated in hepatocellular carcinoma …
(GRP78) and homeobox B9 (HOXB9) are both upregulated in hepatocellular carcinoma …
[HTML][HTML] P4HA2 contributes to cervical cancer progression via inducing epithelial-mesenchymal transition
Y Cao, Q Han, J Li, Y Jia, R Zhang, H Shi - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Background: Cervical cancer is one of the most common gynaecological malignancies.
Emerging studies have documented that prolyl-4-hydroxylase α subunit 2 (P4HA2) is …
Emerging studies have documented that prolyl-4-hydroxylase α subunit 2 (P4HA2) is …
Regulation of molecular chaperone GRP78 by hepatitis B virus: control of viral replication and cell survival
W Shu, Z Guo, L Li, Z Xiong, Z Wang… - … and cellular biology, 2020 - Taylor & Francis
Chronic hepatitis B (CHB) remains a global health problem, carrying a high risk for
progression into cirrhosis and liver failure. Molecular chaperones are involved in diverse …
progression into cirrhosis and liver failure. Molecular chaperones are involved in diverse …
[HTML][HTML] Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement …
Y Zhou, G Jin, R Mi, J Zhang, J Zhang, H Xu, S Cheng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Emerging evidence has demonstrated transdifferentiation process of glioma stem cells
(GSCs) into endothelial cells (ECs) in glioma neovascularization. Herein, we focused on …
(GSCs) into endothelial cells (ECs) in glioma neovascularization. Herein, we focused on …
P4HA2 Promotes Epithelial‐to‐Mesenchymal Transition and Glioma Malignancy through the Collagen‐Dependent PI3K/AKT Pathway
J Lin, L Jiang, X Wang, W Wei, C Song… - Journal of …, 2021 - Wiley Online Library
Prolyl‐4‐hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
[HTML][HTML] Knockdown of GTPBP4 inhibits cell growth and survival in human hepatocellular carcinoma and its prognostic significance
WB Liu, WD Jia, JL Ma, GL Xu, HC Zhou, Y Peng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract GTP-binding protein 4 (GTPBP4), as a novel member of GTPases involved in the
synthesis of 60S subunit and maturation, is closely related to cell proliferation and growth …
synthesis of 60S subunit and maturation, is closely related to cell proliferation and growth …
[HTML][HTML] Targeting P4HA1 with a small molecule inhibitor in a colorectal cancer PDX model
Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …
p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling
P Huang, X Feng, Z Zhao, B Yang, T Fang… - Experimental cell …, 2019 - Elsevier
The development of hepatocellular carcinoma (HCC) is strongly associated with chronic
inflammation. p66Shc is an oxidase previously shown to promote androgen-independent …
inflammation. p66Shc is an oxidase previously shown to promote androgen-independent …