Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

AKT is a central signaling molecule in regulating cell survival, proliferation, tumor growth
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …

Studies using cultured melanoma cells and patient tumor biopsies have demonstrated
deregulated PI3 kinase-Akt3 pathway activity in~ 70% of melanomas. Furthermore, targeting …

Akt regulates critical cellular processes including cell survival and proliferation, glucose
metabolism, cell migration, cancer progression and metastasis through phosphorylation of a …

The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …

The frequent deregulation of the phosphoinositide 3-kinase/Akt survival signaling pathway
in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently …

AKT is a key serine/threonine kinase in the PTEN/PI3K/AKT pathway1 and activation of AKT
is often observed in human cancers. To explore the role of AKT in cell survival in different …

Kinases of the Akt family are integral and essential components in growth factor signaling
pathways activated downstream of the membrane bound phospho-inositol-3 kinase. In light …

Protein Kinase B (PKB), more commonly referred to as Akt, is a serine/threonine-specific
protein kinase. It is well established as a critical signaling node that regulates a myriad of …

Akt, a protein kinase hyperactivated in many tumors, plays a major role in both cell survival
and resistance to tumor therapy. A recent study, 1 along with other evidences, shows …