The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

Native chemical ligation (NCL) provides a highly efficient and robust means to
chemoselectively link unprotected peptide and protein segments to generate proteins. The …

Highlights•Recent progress in ligation chemistry for the synthesis of peptides and proteins is
outlined.•Extensions of native chemical ligation at thiol and selenol amino acids.•New C …

The native chemical ligation enables the chemoselective coupling of two unprotected
protein segments. In the initial format of this reaction, the side chain of N‐terminal cysteine …

The highly chemoselective reaction between unprotected peptides bearing an N-terminal
Cys residue and a C-terminal thioester enables the total and semi-synthesis of complex …

Peptide and protein thioesters are playing an increasingly prominent role in the chemical
toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In …

Of the many approaches proposed to generalize the native chemical ligation approach for
protein synthesis, the simple procedure of global desulfurization of peptide thiols has …

Peptide ligation chemistry has revolutionized protein science by facilitating access to
synthetic proteins. Here, we describe the development of additive-free ligation …

Native chemical ligation is a powerful tool for the convergent assembly of homogeneous
peptide and protein targets from unprotected peptide fragments. The method involves the …

The chemical synthesis of proteins provides synthetic chemists with an interesting challenge
and supports biological research through the generation of proteins that are not produced …