[HTML][HTML] Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor

Y Zhou, S Liu, C Liu, J Yang, Q Lin… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Aims: Using Single-cell RNA sequencing (scRNA-seq), we explored the spatiotemporal
heterogeneity of pancreatic neuroendocrine tumors (pNETs) and the underlying mechanism …

Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …

[HTML][HTML] Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

KC Yang, SE Kalloger, JJ Aird, MKC Lee, C Rushton… - Cell reports, 2021 - cell.com
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically
heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability

N Raj, R Shah, Z Stadler, S Mukherjee, J Chou… - JCO precision …, 2018 - ascopubs.org
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …

[HTML][HTML] Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation

X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …

[HTML][HTML] Molecular signatures and their clinical utility in pancreatic neuroendocrine tumors

PD Chatani, SK Agarwal, SM Sadowski - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (PNETs) are classified based on their histologic
differentiation and proliferative indices, which have been used extensively to determine …

[HTML][HTML] Genomic landscape of pancreatic neuroendocrine tumors

N Gebauer, C Schmidt-Werthern… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To investigate the prognostic role of genomic stability and copy number alterations
(CNAs) pancreatic neuroendocrine tumors (PanNETs). METHODS: A high-resolution array …

Gene expression signatures identify novel therapeutics for metastatic pancreatic neuroendocrine tumors

AT Scott, M Weitz, PJ Breheny, PH Ear, B Darbro… - Clinical Cancer …, 2020 - AACR
Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

M Miki, T Oono, N Fujimori, T Takaoka… - Cancer …, 2019 - Wiley Online Library
Although the postoperative recurrence rate for pancreatic neuroendocrine tumors (PNETs) is
reported to be 13.5%‐30%, the paucity of valuable biomarkers to predict recurrence poses a …