[HTML][HTML] Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity

I Azran, Y Schavinsky-Khrapunsky, M Aboud - Retrovirology, 2004 - Springer
HTLV-1 is the etiological agent of adult T-cell leukemia (ATL), the neurological syndrome
TSP/HAM and certain other clinical disorders. The viral Tax protein is considered to play a …

Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax

K Endo, A Hirata, K Iwai, M Sakurai, M Fukushi… - Journal of …, 2002 - Am Soc Microbiol
Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are retroviruses with similar
biological properties. Whereas HTLV-1 is the causative agent of an aggressive T-cell …

Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades

ML Gatza, JC Watt, SJ Marriott - Oncogene, 2003 - nature.com
The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is
responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated …

[HTML][HTML] Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein

JM Mesnard, C Devaux - Virology, 1999 - Elsevier
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of two diseases: adult T-
cell leukemia (ATL), a fatal T-lymphoproliferative disorder, and tropical spastic …

Mutational analysis of human T-cell leukemia virus type 2 Tax

TM Ross, AC Minella, ZY Fang, SM Pettiford… - Journal of …, 1997 - Am Soc Microbiol
A mutational analysis of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was
performed to identify regions within Tax-2 important for activation of promoters through the …

Molecular mechanisms of cellular transformation by HTLV-1 Tax

R Grassmann, M Aboud, KT Jeang - Oncogene, 2005 - nature.com
The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

Mechanisms of Tax regulation of human T cell leukemia virus type I gene expression

AA Franklin, JK Nyborg - Journal of Biomedical Science, 1995 - karger.com
During the last several years, the human T cell leukemia virus type I (HTLY-I) has become
recognized as an important cause for public health concern throughout the world. HTLY-I is …

The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes

TM Ross, SM Pettiford, PL Green - Journal of virology, 1996 - Am Soc Microbiol
The mechanism of human T-cell leukemia virus (HTLV)-mediated transformation and
induction of malignancy is unknown; however, several studies have implicated the viral …

Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis

M Sieburg, A Tripp, JW Ma, G Feuer - Journal of virology, 2004 - Am Soc Microbiol
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia
and lymphoma, an aggressive clonal malignancy of human CD4-bearing T lymphocytes …

HTLV-1 Tax: linking transformation, DNA damage and apoptotic T-cell death

K Chlichlia, K Khazaie - Chemico-biological interactions, 2010 - Elsevier
The human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4-positive T-cell neoplasia. The HTLV-1 proto-oncogene …