HTLV-I Tax and cell cycle progression

C Neuveut, KT Jeang - Progress in cell cycle research, 1998 - Springer
Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia
(ATL) and various human myopathies/neuropathies. HTLV-I encodes a 40 kDa …

Secretion of the human T cell leukemia virus type I transactivator protein tax

T Alefantis, K Mostoller, P Jain, E Harhaj… - Journal of Biological …, 2005 - ASBMB
Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia
and HTLV-I-associated myelopathy/tropical spastic paraparesis. The HTLV-I protein Tax is …

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

S Niewiesk, S Daenke, CE Parker, G Taylor… - Journal of …, 1995 - Am Soc Microbiol
There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-
cell leukemia virus type I (HTLV-I), although the sequence variation between patients is …

Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma

S Mitra-Kaushik, J Harding, J Hess, R Schreiber… - Blood, 2004 - ashpublications.org
The oncoprotein Tax of human T-cell leukemia virus type I (HTLV-1) is the major mediator of
viral pathogenesis in infected individuals. Expression of Tax under the regulation of the …

Accelerated G1 phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein

FJ Lemoine, SJ Marriott - Journal of Biological Chemistry, 2001 - ASBMB
Tax, the human T cell leukemia virus type I oncoprotein, plays a crucial role in viral
transformation and the development of the virally associated disease adult T cell leukemia …

Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation

F Bex, K Murphy, R Wattiez, A Burny… - Journal of virology, 1999 - Am Soc Microbiol
The Tax transactivator protein of human T-cell leukemia virus type 1 (HTLV-1) plays a
central role in the activation of viral gene expression. In addition, Tax is capable of activating …

Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax

H Kwon, L Ogle, B Benitez, J Bohuslav… - Journal of Biological …, 2005 - ASBMB
Type I human T cell leukemia virus (HTLV-I) is etiologically linked with adult T cell leukemia,
an aggressive and usually fatal expansion of activated CD4+ T lymphocytes that frequently …

Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome

H Miyake, T Suzuki, H Hirai, M Yoshida - Virology, 1999 - Elsevier
Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent trans-activator of
specific sets of target genes, and on the other hand, it is a trans-repressor of other sets of …

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

R Currer, R Van Duyne, E Jaworski, I Guendel… - Frontiers in …, 2012 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response

A Haoudi, RC Daniels, E Wong, G Kupfer… - Journal of Biological …, 2003 - ASBMB
The virally encoded oncoprotein Tax has been implicated in HTLV-1-mediated cellular
transformation. The exact mechanism by which this protein contributes to the oncogenic …