Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation
KT Jeang, C Giam, F Majone, M Aboud - Journal of Biological Chemistry, 2004 - ASBMB
Human T-cell leukemia virus type I (HTLV-I) 1 causes adult T-cell leukemia (ATL)(1–3). The
virus is also associated with a neuropathy/myelopathy termed HTLV-associated myelopathy …
virus is also associated with a neuropathy/myelopathy termed HTLV-associated myelopathy …
Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Tax trans-Activation of Proliferating Cell Nuclear Antigen Gene Expression
FJ Lemoine, SY Kao, SJ Marriott - AIDS research and human …, 2000 - liebertpub.com
The human T cell leukemia virus type 1 (HTLV-1) viral oncoprotein Tax acts as a
transcriptional trans-activator affecting viral as well as cellular gene expression. To …
transcriptional trans-activator affecting viral as well as cellular gene expression. To …
Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins
OJ Semmes, KT Jeang - Journal of virology, 1992 - Am Soc Microbiol
We have made 47 mutations that span the length of the human T-cell leukemia virus type I
(HTLV-I) Tax open reading frame. Of the 47 mutations, 38 were substitutions of single amino …
(HTLV-I) Tax open reading frame. Of the 47 mutations, 38 were substitutions of single amino …
Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-κB2 p100 gene product: implications for viral latency
C Béraud, SC Sun, P Ganchi, DW Ballard… - … and cellular biology, 1994 - Am Soc Microbiol
Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell
leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells. HTLV-I …
leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells. HTLV-I …
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein
JM Peloponese, KT Jeang - Journal of Biological Chemistry, 2006 - ASBMB
Human T-cell leukemia virus type 1 is an oncogenic retrovirus etiologically causal of adult T-
cell leukemia. The virus encodes a Tax oncoprotein, which functions in transcriptional …
cell leukemia. The virus encodes a Tax oncoprotein, which functions in transcriptional …
Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-κB and c-AMP responsive …
N Mori, M Fujii, G Cheng, S Ikeda, Y Yamasaki… - Virus genes, 2001 - Springer
Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), which is an aggressive form of human T-cell malignancy. The viral protein, Tax …
(ATL), which is an aggressive form of human T-cell malignancy. The viral protein, Tax …
Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells
Infection with the human T-cell leukemia virus-1 (HTLV-1) results in a variety of diseases
including adult T-cell leukemia/lymphoma (ATL). Although the pathogenesis of these …
including adult T-cell leukemia/lymphoma (ATL). Although the pathogenesis of these …
Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice
T Zhao, Y Satou, M Matsuoka - Archives of virology, 2014 - Springer
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1). ATL cells possess a CD4+ CD25+ phenotype, similar to that …
leukemia virus type 1 (HTLV-1). ATL cells possess a CD4+ CD25+ phenotype, similar to that …
Tumor immunity against adult T‐cell leukemia
M Kannagi, N Harashima, K Kurihara, T Ohashi… - Cancer …, 2005 - Wiley Online Library
Human T‐cell leukemia virus type‐I (HTLV‐I) causes adult T‐cell leukemia (ATL) in a small
population of infected individuals after a long incubation period. Although the process of …
population of infected individuals after a long incubation period. Although the process of …
HTLV-I Tax-dependent and-independent events associated with immortalization of human primary T lymphocytes
M Bellon, HH Baydoun, Y Yao… - Blood, The Journal of the …, 2010 - ashpublications.org
Human T-cell leukemia virus type I (HTLV-I)–associated malignancies are seen in a small
percentage of infected persons. Although in vitro immortalization by HTLV-I virus is very …
percentage of infected persons. Although in vitro immortalization by HTLV-I virus is very …