The human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive T-
cell malignancy in humans. While the virus appears to maintain a state of latency in most …

The oncogenic potential of the HTLV-1 Tax protein involves activation of the NF-κB pathway,
which depends on Tax phosphorylation, ubiquitination and sumoylation. We demonstrate …

The tax protein of Human T-cell leukemia virus type 1 (HTLV-1) is important for the
transforming properties of this virus in vitro and is considered to be responsible for the early …

Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-
cell leukemia (ATL), whereas HTLV type 2 (HTLV-2), is not associated with ATL or any other …

Human T lymphotropic virus type 1 (HTLV-1) Tax is a multifunctional protein centrally
involved in transcriptional regulation, cell cycle control, and viral transformation. The …

Epidemiologic studies have linked infection by the human T-lymphotropic virus type I (HTLV-
I) with the development of adult T-cell leukemia. The low penetrance of the virus and the …

MATERIALS AND METHODS Antibodies and plasmids. pHTLV-1 LTR-luc, NF-B-luc, pHA-
ubiquitin, pMyc-ubiquitin, and pHis-ubiquitin were described previously (2, 23). HASUMO …

Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous
research has established that the viral oncoprotein Tax mediates the transformation process …

Tax, the transforming protein of human T-cell leukemia virus type 1 (HTLV-1), is required for
strong activation of HTLV-1 transcription. This activation is mediated through interaction with …

We have isolated and characterized revertants of a clonal cell line (40MRatcl-1) of human T-
cell leukemia virus type I Tax-transformed Rat1 cells. The 40MRatcl-1 cells contain a single …