Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis …

Y Furukawa, M Osame, R Kubota, M Tara, M Yoshida - 1995 - ashpublications.org
Patients with human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy
(HAM/TSP) generally harbor a much greater population of HTLV-1-infected T cells in …

Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein

SS Durkin, MD Ward, KA Fryrear… - Journal of Biological …, 2006 - ASBMB
The human T-cell leukemia virus type 1 oncoprotein Tax is a phosphoprotein with a
predominately nuclear subcellular localization that accomplishes multiple functions via …

A human T-cell leukemia virus Tax variant incapable of activating NF-κB retains its immortalizing potential for primary T-lymphocytes

O Rosin, C Koch, I Schmitt, OJ Semmes… - Journal of Biological …, 1998 - ASBMB
The human T-cell leukemia virus type 1 (HTLV-1) transactivator (Tax) has been shown to
interfere with regulated cellular proliferation. Many studies have focused on the ability of Tax …

Leukaemogenic mechanism of human T‐cell leukaemia virus type I

J Yasunaga*, M Matsuoka - Reviews in Medical Virology, 2007 - Wiley Online Library
Adult T‐cell leukaemia (ATL) is a neoplastic disease derived from CD4+ T‐lymphocytes and
etiologically associated with human T‐cell leukaemia virus type I (HTLV‐I). In addition to …

TheCentral Region of Human T-Cell Leukemia Virus Type 1 TaxProtein Contains Distinct Domains Involved inSubunitDimerization

J Basbous, A Bazarbachi, C Granier, C Devaux… - Journal of …, 2003 - Am Soc Microbiol
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) can form homodimers. Tax
dimerization contributes to optimal Tax activity involved in transactivation of the HTLV-1 …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb

C Neuveut, KG Low, F Maldarelli, I Schmitt… - … and cellular biology, 1998 - Am Soc Microbiol
Human T-cell leukemia virus type 1 is etiologically linked to the development of adult T-cell
leukemia and various human neuropathies. The Tax protein of human T-cell leukemia virus …

Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control

K Van Orden, J Yan, A Ulloa, JK Nyborg - Oncogene, 1999 - nature.com
Abstract The HTLV-I oncoprotein Tax is required for high level viral transcription and is
strongly linked to HTLV-I-associated malignant transformation. Tax stimulates HTLV-I …

New insight into the oncogenic mechanism of the retroviral oncoprotein Tax

H Cheng, T Ren, S Sun - Protein & cell, 2012 - Springer
HTLV-1 viral genome encodes three main structural gene products including Gag, reverse
transcriptase (Pol/RT) and envelope protein (Env), and it also expresses several viral …

CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein

KV Kibler, KT Jeang - Journal of virology, 2001 - Am Soc Microbiol
Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated
with cellular transformation contributing to the development of adult T-cell leukemia. Tax has …