HTLV-1 viral genome encodes three main structural gene products including Gag, reverse
transcriptase (Pol/RT) and envelope protein (Env), and it also expresses several viral …

Genomic instability, a hallmark of leukemic cells, is associated with malfunctioning cellular
responses to DNA damage caused by defective cell cycle checkpoints and/or DNA repair …

MATERIALS AND METHODS Plasmids. The wild-type tax and tax mutant genes were
cloned into pHβPr. 1-neo, which has a β-actin promoter for protein expression in vivo as well …

Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated
with cellular transformation contributing to the development of adult T-cell leukemia. Tax has …

Human T cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in 2–5% of
carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and …

Human T-cell leukemia virus I is the etiologic agent of adult T-cell leukemia (ATL), an
aggressive T-cell malignancy. The viral oncoprotein Tax, through the activation of nuclear …

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell
leukemia/lymphoma and is associated with a variety of immunoregulatory disorders. HTLV-1 …

Human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia
(ATL). To elucidate the role of HTLV-I in leukemogenesis, we examined the biological …

Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia
(ATL), is estimated to affect 10–20 million people worldwide. The transforming ability of …

A 42‐kDa recombinant protein, PX141, consisting of the trans‐activator protein encoded by
human T‐cell leukemia virus (HTLV‐I)(tax, antigen) and the amino‐terminal fusion peptide …