Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells

K Iwai, N Mori, M Oie, N Yamamoto, M Fujii - Virology, 2001 - Elsevier
Human T-cell leukemia virus type 1 (HTLV-1) Tax protein induces the expression of various
family members of the transcription factor AP-1, such as c-Jun, JunD, c-Fos, and Fra-1, at the …

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

X Xu, SH Kang, O Heidenreich… - The Journal of …, 1995 - Am Soc Clin Investig
HTLV-1 infection causes an adult T cell leukemia in humans. The viral encoded protein tax,
is thought to play an important role in oncogenesis. Our previous data obtained from a tax …

Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex

YP Ching, ACS Chun, KT Chin, ZQ Zhang, KT Jeang… - Retrovirology, 2004 - Springer
Background Human T-cell leukemia virus type I (HTLV-I) Tax protein is a transcriptional
regulator of viral and cellular genes. In this study we have examined in detail the …

HTLV deregulation of the NF-κB pathway: An update on tax and antisense proteins role

S Fochi, S Mutascio, U Bertazzoni, D Zipeto… - Frontiers in …, 2018 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4+/CD25+ T-cell malignancy and of a severe …

Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors.

MN Uittenbogaard, AP Armstrong… - Journal of Biological …, 1994 - ASBMB
The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax is a potent activator of viral
and cellular gene transcription. Tax does not bind DNA directly but utilizes cellular …

Association between HTLV-1 Tax and IκBα is dependent on the IκBα phosphorylation state

L Petropoulos, J Hiscott - Virology, 1998 - Elsevier
Biological, molecular, and epidemiological data have demonstrated that human T cell
leukemia virus type 1 (HTLV-1) encoded Tax protein plays a central role in the initiation of T …

In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein

MAH Matthews, RB Markowitz… - Molecular and cellular …, 1992 - Am Soc Microbiol
The human T-cell leukemia virus type I (HTLV-I) regulatory protein Tax activates
transcription of the proviral long terminal repeats and a number of cellular promoters. We …

Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation

M Shirinian, Y Kfoury, Z Dassouki, H El-Hajj… - Frontiers in …, 2013 - frontiersin.org
Although human T cell leukemia virus type 1 and 2 (HTLV-1 and HTLV-2) share similar
genetic organization, they have major differences in their pathogenesis and disease …

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

S Ressler, GF Morris, SJ Marriott - Journal of virology, 1997 - Am Soc Microbiol
The human T-cell leukemia virus type 1 (HTLV-1) transforming protein, Tax, is a potent
transactivator of both viral and cellular gene expression. The ability of Tax to transform cells …

[PDF][PDF] HTLV-1 Tax and adult T-cell leukemia

CZ Giam, KT Jeang - Front Biosci, 2007 - researchgate.net
Introduction 3. HTLV-1 Related Diseases 3.1. Adult T-cell leukemia/lymphoma (ATL) 3.2.
HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP), HTLV-1 uveitis …