Endosomal escape: a bottleneck in intracellular delivery

HK Shete, RH Prabhu… - Journal of nanoscience …, 2014 - ingentaconnect.com
With advances in therapeutic science, apart from drugs, newer bioactive moieties like
oligonucleotides, proteins, peptides, enzymes and antibodies are constantly being …

Endosomal escape pathways for delivery of biologicals

AK Varkouhi, M Scholte, G Storm, HJ Haisma - Journal of Controlled …, 2011 - Elsevier
Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

Overcoming endosomal entrapment in drug delivery

D Pei, M Buyanova - Bioconjugate chemistry, 2018 - ACS Publications
Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles

AM Butt, N Abdullah, NNIM Rani, N Ahmad… - Pharmaceutical …, 2022 - Springer
Cytoplasmic delivery of bioactives requires the use of strategies such as active transport,
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …

Challenges in carrier‐mediated intracellular delivery: moving beyond endosomal barriers

MP Stewart, A Lorenz, J Dahlman… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
The deployment of molecular to microscale carriers for intracellular delivery has tremendous
potential for biology and medicine, especially for in vivo therapies. The field remains limited …

Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles

A Ahmad, JM Khan, S Haque - Biochimie, 2019 - Elsevier
Nanoparticles (NPs) are one of the leading and promising technologies for gene and drug
delivery. However, despite continuous advancements in the delivery of NPs, endosomal …

Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles

E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery

C Qiu, F Xia, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

LI Selby, CM Cortez‐Jugo, GK Such… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment
of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing …

The endosomal escape of nanoparticles: toward more efficient cellular delivery

SA Smith, LI Selby, APR Johnston… - Bioconjugate …, 2018 - ACS Publications
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …