Experimental measurement of extravascular parenchymal BOLD effects and tissue oxygen extraction fractions using multi‐echo VASO fMRI at 1.5 and 3.0 T

H Lu, PCM Van Zijl - … in Medicine: An Official Journal of the …, 2005 - Wiley Online Library
Quantitative interpretation of BOLD fMRI signal changes has predominantly employed
empirical models for the whole parenchyma and a calibration step is usually needed to …

Diffusion‐weighted spin‐echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal changes

SP Lee, AC Silva, K Ugurbil… - Magnetic Resonance in …, 1999 - Wiley Online Library
The nature of vascular contribution to blood oxygenation level dependent (BOLD) contrast
used in functional MRI (fMRI) is poorly understood. To investigate vascular contributions at …

Quantitative differentiation between BOLD models in fMRI

FGC Hoogenraad, PJW Pouwels… - … in Medicine: An …, 2001 - Wiley Online Library
Several gradient‐echo fMRI blood oxygenation level‐dependent (BOLD) effects are
described in the literature: extravascular spin dephasing around capillaries and veins …

Comparison of the dependence of blood R2 and R on oxygen saturation at 1.5 and 4.7 Tesla

MJ Silvennoinen, CS Clingman, X Golay… - … in Medicine: An …, 2003 - Wiley Online Library
Gradient‐echo (GRE) blood oxygen level‐dependent (BOLD) effects have both intra‐and
extravascular contributions. To better understand the intravascular contribution in …

Source of nonlinearity in echo‐time‐dependent BOLD fMRI

T Jin, P Wang, M Tasker, F Zhao… - Magnetic Resonance in …, 2006 - Wiley Online Library
Stimulation‐induced changes in transverse relaxation rates can provide important insight
into underlying physiological changes in blood oxygenation level‐dependent (BOLD) …

A review of the development of Vascular-Space-Occupancy (VASO) fMRI

H Lu, PCM van Zijl - Neuroimage, 2012 - Elsevier
Vascular-Space-Occupancy (VASO) fMRI is a non-invasive technique to detect brain
activation based on changes in Cerebral Blood Volume (CBV), as opposed to conventional …

Experimental determination of the BOLD field strength dependence in vessels and tissue

JS Gati, RS Menon, K Uǧurbil… - Magnetic resonance in …, 1997 - Wiley Online Library
High resolution functional MRI (fMRI) experiments were performed in human visual cortex at
0.5, 1.5, and 4 T to determine the blood oxygenation level dependent (BOLD) field strength …

Investigation of the initial dip in fMRI at 7 Tesla

E Yacoub, A Shmuel, J Pfeuffer… - NMR in Biomedicine …, 2001 - Wiley Online Library
In agreement with optical imaging studies, previous fMRI studies have reported an initial
decrease (ie the initial dip) in the BOLD response, which is believed to arise from an …

Extravascular contribution of blood oxygenation level‐dependent signal changes: a numerical analysis based on a vascular network model

N Fujita - Magnetic Resonance in Medicine: An Official Journal …, 2001 - Wiley Online Library
In this study, the extravascular (EV) contribution to blood oxygenation level‐dependent
(BOLD) signal changes was evaluated, based on a numerical analysis of the …

Microvascular BOLD contribution at 4 and 7 T in the human brain: gradient‐echo and spin‐echo fMRI with suppression of blood effects

TQ Duong, E Yacoub, G Adriany, X Hu… - … in Medicine: An …, 2003 - Wiley Online Library
The BOLD signal consists of an intravascular (IV) and an extravascular (EV) component from
both small and large vessels. Their relative contributions are dependent on field strength …