The contributory role of gut microbiota in cardiovascular disease

WHW Tang, SL Hazen - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Our group recently discovered that certain dietary nutrients possessing a trimethylamine
(TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the …

Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis

K Kasahara, T Tanoue, T Yamashita, K Yodoi… - Journal of lipid …, 2017 - ASBMB
The gut microbiota were shown to play critical roles in the development of atherosclerosis,
but the detailed mechanism is limited. The purpose of this study is to clarify the influence of …

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

N Paeslack, M Mimmler, S Becker, Z Gao, MP Khuu… - Amino Acids, 2022 - Springer
The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in
compounds that affect innate immune cell functions directly, but also acting on the aryl …

Association between the gut microbiome and atherosclerosis

WT Barrington, AJ Lusis - Nature Reviews Cardiology, 2017 - nature.com
The gut microbiota has been associated with many different disorders, including
cardiovascular diseases. A new study by Jie and colleagues is the first large case–control …

Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality

I Nemet, XS Li, A Haghikia, L Li, J Wilcox… - European Heart …, 2023 - academic.oup.com
Aims Precision microbiome modulation as a novel treatment strategy is a rapidly evolving
and sought goal. The aim of this study is to determine relationships among systemic gut …

The emerging role of gut microbial metabolism on cardiovascular disease

K Kasahara, FE Rey - Current opinion in microbiology, 2019 - Elsevier
Highlights•Clinical cohorts show associations between gut microbiome and CVD.•Products
of microbial metabolism derived from diet are linked with progression of CVD.•Microbes are …

Metabolic products of the intestinal microbiome and extremes of atherosclerosis

C Bogiatzi, G Gloor, E Allen-Vercoe, G Reid, RG Wong… - Atherosclerosis, 2018 - Elsevier
Background and aims There is increasing awareness that the intestinal microbiome plays an
important role in human health. We investigated its role in the burden of carotid …

Biological effects of indole-3-propionic acid, a gut microbiota-derived metabolite, and its precursor tryptophan in mammals' health and disease

P Konopelski, I Mogilnicka - International journal of molecular sciences, 2022 - mdpi.com
Actions of symbiotic gut microbiota are in dynamic balance with the host's organism to
maintain homeostasis. Many different factors have an impact on this relationship, including …

Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Role of gut microbiota in chronic low‐grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

ICL van den Munckhof, A Kurilshikov… - Obesity …, 2018 - Wiley Online Library
A hallmark of obesity is chronic low‐grade inflammation, which plays a major role in the
process of atherosclerotic cardiovascular disease (ACVD). Gut microbiota is one of the …