The gut microbiota-produced indole-3-propionic acid confers the antihyperlipidemic effect of mulberry-derived 1-deoxynojirimycin
Y Li, W Xu, F Zhang, S Zhong, Y Sun, J Huo, J Zhu… - Msystems, 2020 - Am Soc Microbiol
Hyperlipidemia is a worldwide epidemic with an obvious gender disparity in incidence.
Modulations on gut microbiota by traditional Chinese medicines (TCM) are emerging as a …
Modulations on gut microbiota by traditional Chinese medicines (TCM) are emerging as a …
[HTML][HTML] Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
M Tuomainen, J Lindström, M Lehtonen, S Auriola… - Nutrition & …, 2018 - nature.com
We recently reported using non-targeted metabolic profiling that serum indolepropionic acid
(IPA), a microbial metabolite of tryptophan, was associated with a lower likelihood of …
(IPA), a microbial metabolite of tryptophan, was associated with a lower likelihood of …
[HTML][HTML] Ferulic acid ameliorates atherosclerotic injury by modulating gut microbiota and lipid metabolism
Y Gu, Y Zhang, M Li, Z Huang, J Jiang… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a leading cause of death worldwide. Recent studies have emphasized the
significance of gut microbiota and lipid metabolism in the development of atherosclerosis …
significance of gut microbiota and lipid metabolism in the development of atherosclerosis …
Gut microbiota-associated activation of TLR5 induces apolipoprotein A1 production in the liver
JHC Yiu, KS Chan, J Cheung, J Li, Y Liu… - Circulation …, 2020 - Am Heart Assoc
Rationale: Dysbiosis of gut microbiota plays an important role in cardiovascular diseases but
the molecular mechanisms are complex. An association between gut microbiome and the …
the molecular mechanisms are complex. An association between gut microbiome and the …
[HTML][HTML] Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
SR Ma, Q Tong, Y Lin, LB Pan, J Fu, R Peng… - Signal transduction and …, 2022 - nature.com
Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic
metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO …
metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO …
Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the …
M Chen, L Yi, Y Zhang, X Zhou, L Ran, J Yang, J Zhu… - MBio, 2016 - Am Soc Microbiol
The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol
(RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action …
(RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action …
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe−/− Mice
Background—Altered composition of the gut microbiota is involved in both the onset and
progression of obesity and diabetes mellitus. However, the link between gut microbiota and …
progression of obesity and diabetes mellitus. However, the link between gut microbiota and …
[HTML][HTML] Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut …
X Li, C Su, Z Jiang, Y Yang, Y Zhang, M Yang… - npj Biofilms and …, 2021 - nature.com
Abstract Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite
trimethylamine (TMA), has been identified to be an independent risk factor for promoting …
trimethylamine (TMA), has been identified to be an independent risk factor for promoting …
Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3
T Luo, Z Guo, D Liu, Z Guo, Q Wu, Q Li, R Lin… - Gut …, 2022 - Taylor & Francis
Maladaptive inflammatory and immune responses are responsible for intestinal barrier
integrity and function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) …
integrity and function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) …
[HTML][HTML] Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
Gut microbiota promotes atherosclerosis, and vascular endothelial dysfunction, signalled by
impaired endothelium-dependent vasorelaxation, is an early marker of atherosclerosis. Here …
impaired endothelium-dependent vasorelaxation, is an early marker of atherosclerosis. Here …