We show that DNA enzymes (deoxyribozymes) can introduce azide functional groups at
tyrosine residues in peptide substrates. Using in vitro selection, we identified …

Deoxyribozymes are particular DNA sequences that have catalytic ability, analogous to
protein enzymes as functional amino acid sequences.[1, 2] The discovery of natural RNA …

This study focuses on the development of DNA catalysts (deoxyribozymes) that modify side
chains of peptide substrates, with the long-term goal of achieving DNA-catalyzed covalent …

We report DNA catalysts (deoxyribozymes) that join tyrosine‐containing peptides to RNA
and DNA in one step and without requiring protecting groups on either the peptide or the …

Site-specific covalent modification of RNA is important for enabling structure–function
studies. For example, probes such as fluorescein are commonly used in fluorescence …

DNA -catalyzed serine side chain reactivity and selectivity - Chemical Communications (RSC
Publishing) DOI:10.1039/B927317D Royal Society of Chemistry View PDF VersionPrevious …

We show that DNA catalysts (deoxyribozymes, DNA enzymes) can phosphorylate tyrosine
residues of peptides. Using in vitro selection, we identified deoxyribozymes that transfer the …

Conspectus Catalysis is a fundamental chemical concept, and many kinds of catalysts have
considerable practical value. Developing entirely new catalysts is an exciting challenge …

We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to
recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes …

Deoxyribozymes (DNA enzymes) have been developed for a growing variety of chemical
reactions, including with peptide substrates. We recently described the first tyrosine kinase …