Uracil-DNA glycosylase (Ung) is a component of the base excision repair process and has
the ability to remove uracil from U: G mispairs in DNA. However, its implications in …

In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-
formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases and excision of …

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms
and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5 …

DNA methylation is dynamic through the life of an organism. Previous studies have primarily
focused on DNA methylation changes during very early embryogenesis. In this study, global …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

Uracil arises in DNA from spontaneous deamination of cytosine and through incorporation of
dUMP by DNA polymerase during DNA replication. Excision of uracil by the action of uracil …

DNA methylation constitutes an important epigenetic factor in the control of genetic
information. In this study, we analyzed expression of the DNA methyltransferase gene and …

We report the determination of zebrafish DNA (cytosine-5-) methyltransferase (dnmt-1)
temporal and spatial patterns of expression in gonadal tissues and during early …

The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A
previous study that utilized zebrafish embryos provided a potent mechanism for active …