[HTML][HTML] Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors …

AL Pehrson, SC Leiser, M Gulinello, E Dale, Y Li… - European journal of …, 2015 - Elsevier
Although major depressive disorder is primarily considered a mood disorder, depressed
patients commonly present with clinically significant cognitive dysfunction that may add to …

Cognitive impairment in depression: recent advances and novel treatments

G Perini, M Cotta Ramusino, E Sinforiani… - Neuropsychiatric …, 2019 - Taylor & Francis
In the past, little or no attention was paid to cognitive disorders associated with depression
(a condition sometimes termed pseudodementia). However, recent years have seen a …

Vortioxetine for cognitive enhancement in major depression: from animal models to clinical research

D Bennabi, E Haffen, V Van Waes - Frontiers in psychiatry, 2019 - frontiersin.org
Objectives: Vortioxetine has already shown its efficacy in the acute and long-term treatment
of major depressive disorder (MDD) and its potential interest in the prevention of relapse …

Vortioxetine reduces BOLD signal during performance of the N-back working memory task: a randomised neuroimaging trial in remitted depressed patients and …

J Smith, M Browning, S Conen, R Smallman… - Molecular …, 2018 - nature.com
Cognitive dysfunction is common in depression during both acute episodes and remission.
Vortioxetine is a novel multimodal antidepressant that has improved cognitive function …

[HTML][HTML] The effects of vortioxetine on cognitive dysfunction in patients with inadequate response to current antidepressants in major depressive disorder: a short-term …

E Vieta, LB Sluth, CK Olsen - Journal of affective disorders, 2018 - Elsevier
Abstract Background Major Depressive Disorder (MDD) is a heterogeneous disease
characterized by emotional, physical and cognitive symptoms. This study explored the …

Vortioxetine: a review in cognitive dysfunction in depression

JE Frampton - Drugs, 2016 - Springer
Abstract Vortioxetine (Brintellix®; Trintellix®), a generally efficacious and well tolerated
antidepressant agent, is approved in the EU and USA for the treatment of major depressive …

Recognition and treatment of cognitive dysfunction in major depressive disorder

H Zuckerman, Z Pan, C Park, E Brietzke… - Frontiers in …, 2018 - frontiersin.org
Major Depressive Disorder (MDD) is a prevalent, chronic, disabling, and multidimensional
mental disorder. Cognitive dysfunction represents a core diagnostic and symptomatic …

Cognitive remission: a novel objective for the treatment of major depression?

B Bortolato, KW Miskowiak, CA Köhler, M Maes… - BMC medicine, 2016 - Springer
Background Cognitive dysfunction in major depressive disorder (MDD) encompasses
several domains, including but not limited to executive function, verbal memory, and …

Vortioxetine: a review of efficacy, safety and tolerability with a focus on cognitive symptoms in major depressive disorder

M Al-Sukhni, NA Maruschak… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Vortioxetine is a pharmacodynamically novel antidepressant that exerts effects
on various neurotransmitters including serotonin, noradrenaline, dopamine, glutamate …

Pharmacological treatment of cognitive symptoms in major depressive disorder

Z Pan, RC Grovu, DS Cha, NE Carmona… - CNS & Neurological …, 2017 - ingentaconnect.com
Background: Cognitive dysfunction is a core transdiagnostic domain of Major Depressive
Disorder (MDD) and is a principal determinant of functional recovery. However, it has been …