Neurodegeneration and–protection in autoimmune CNS inflammation

R Diem, MB Sättler, M Bähr - Journal of neuroimmunology, 2007 - Elsevier
Neurodegeneration in multiple sclerosis (MS) is the structural correlate of permanent
neurological disability in patients. The histopathological features of neurodegeneration …

Neurodegeneration in autoimmune CNS inflammation

J Herz, F Zipp, V Siffrin - Experimental neurology, 2010 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system, in which the myelin sheath has been considered to be the primary target for …

Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets

O Aktas, S Waiczies, F Zipp - Journal of Neuroimmunology, 2007 - Elsevier
Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central
nervous system (CNS) and the major cause of neurological disability in young adults in …

Novel therapeutic targets for axonal degeneration in multiple sclerosis

S Petratos, MF Azari, E Ozturk… - … of Neuropathology & …, 2010 - academic.oup.com
Multiple sclerosis (MS) is a devastating neurological condition that mainly affects young
adults and is associated with long-standing morbidity. The pathophysiology of MS is …

Neurodegeneration in multiple sclerosis: novel treatment strategies

F Luessi, V Siffrin, F Zipp - Expert Review of Neurotherapeutics, 2012 - Taylor & Francis
In recent years it has become clear that the neuronal compartment already plays an
important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course …

CNS inflammation and neurodegeneration

T Chitnis, HL Weiner - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Multiple sclerosis: a battle between destruction and repair

JL McQualter, CCA Bernard - Journal of neurochemistry, 2007 - Wiley Online Library
Multiple sclerosis (MS) is a chronic neurodegenerative disease of the CNS in which an
unrelenting attack from the innate and adaptive arms of the immune system results in …

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

E Ellwardt, F Zipp - Experimental neurology, 2014 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central
nervous system (CNS) and one of the leading causes of neurological deficits and disability …

Immune-mediated CNS damage

K Kierdorf, Y Wang, H Neumann - … Basis of Multiple Sclerosis: The Immune …, 2010 - Springer
Multiple sclerosis (MS) is a demyelinating autoimmune disease. However, the persisting
neurological deficits in MS patients result from acute axonal injury and chronic …

Immune-mediated oligodendrocyte injury in multiple sclerosis: molecular mechanisms and therapeutic interventions

M Buntinx, P Stinissen, P Steels… - Critical Reviews™ in …, 2002 - dl.begellhouse.com
In this review, new insights into the immunopathogenesis of multiple sclerosis (MS) are
discussed, with special focus on the potential mechanisms leading to neuroinflammation in …