Simple Summary Cell surface proteases (so-called ectoproteases) are associated with
cancer, and their targeting may confer valuable options for the improvement of cancer …

The role of proteases in cancer was originally thought to be limited to the breakdown of
basement membranes and extracellular matrix (ECM), thereby promoting cancer cell …

Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

Pericellular proteolysis provides a significant advantage to developing tumors through the
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …

Proteolysis plays critical roles in normal and pathologic physiology; these enzymes are
intricately involved in cancer progression and spread. Our understanding of protease …

There is an extensive body of literature documenting the association of proteases with
cancer. Indeed, a search of PubMed for the phrase “proteases in cancer” brings up a list of …

Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

Proteostasis is the process of regulating intracellular proteins to maintain the balance of the
cell proteome, which is crucial for cancer cell survival. Several proteases located in the …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Alternative splicing of precursor mRNA is a key mediator of gene expression regulation
leading to greater diversity of the proteome in complex organisms. Systematic sequencing of …