Bioinformatics tools have facilitated the reconstruction and analysis of cellular metabolism of
various organisms based on information encoded in their genomes. Characterization of …

Metabolic network analysis has attracted much attention in the area of systems biology. It
has a profound role in understanding the key features of organism metabolic networks and …

Mathematical modelling is a powerful tool for the organisation and analysis of biological
data. Both stoichiometric and kinetic models have been applied to the investigation of …

Metabolic pathways have become increasingly available for various microorganisms. Such
pathways have spurred the development of a wide array of computational tools, in particular …

Metabolic engineering serves as an integrated approach to design new cell factories by
providing rational design procedures and valuable mathematical and experimental tools …

In this chapter, the process for the reconstruction of genome-scale metabolic networks is
described, and some of the main applications of such models are illustrated. The …

Motivation: Information from fully sequenced genomes makes it possible to reconstruct strain-
specific global metabolic network for structural and functional studies. These networks are …

Genome-scale metabolic models of organisms can be reconstructed using annotated
genome sequence information, well-curated databases, and primary research literature. The …

Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …

A great variety of software applications are now employed in the metabolic engineering field.
These applications have been created to support a wide range of experimental and analysis …