Lineage of bone marrow–derived cells in atherosclerosis

H Iwata, I Manabe, R Nagai - Circulation research, 2013 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease driven by lipids and other atherogenic
factors. It is characterized by a dynamic and complex pathological process of bone marrow …

Loss of bone marrow-derived vascular progenitor cells leads to inflammation and atherosclerosis

PJ Goldschmidt-Clermont - American heart journal, 2003 - Elsevier
BACKGROUND: Aging represents the most powerful risk for the development of
atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by …

Myeloid cells in atherosclerosis: initiators and decision shapers

O Soehnlein, C Weber - Seminars in immunopathology, 2009 - Springer
Chronic inflammation is the underlying pathophysiological mechanism of atherosclerosis.
Prominent suspects being involved in atherosclerosis are lymphocytes, platelets, and …

Hematopoiesis and cardiovascular disease

WC Poller, M Nahrendorf, FK Swirski - Circulation research, 2020 - Am Heart Assoc
A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Cholesterol and hematopoietic stem cells: inflammatory mediators of atherosclerosis

JK Lang, TR Cimato - Stem cells translational medicine, 2014 - academic.oup.com
Atherosclerosis causing heart attack and stroke is the leading cause of death in the modern
world. Therapy for end-stage atherosclerotic disease using CD34+ hematopoietic cells has …

Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

MP Noz, S Bekkering, L Groh, TMJ Nielen… - Elife, 2020 - elifesciences.org
Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived
macrophages are the most abundant immune cells in atherosclerotic plaques. In patients …

Atherosclerosis 2005: recent discoveries and novel hypotheses

PJ Goldschmidt-Clermont, MA Creager, DW Lorsordo… - Circulation, 2005 - Am Heart Assoc
Atherosclerosis is an inflammatory process that selec-tively affects arteries and is highly
prevalent in both women and men. Thrombo-occlusive complications of atherosclerosis …

[HTML][HTML] Bone marrow–derived cells and arterial disease

J Golledge, A Van Campenhout, S Pal… - Journal of vascular surgery, 2007 - Elsevier
This article reviews the association between bone and artery disease, with particular
relevance to progenitor cells. The review was based on insight gained by analysis of …

Vascular disease: a new progenitor biology

P Metharom, NM Caplice - Current vascular pharmacology, 2007 - ingentaconnect.com
Vascular disease is primarily the result of atherosclerosis which affects all layers of the adult
vessel wall. Our understanding of atherosclerosis has evolved over the past three decades; …

Maintenance of Vascular Homeostasis by Bone Marrow–Derived Cells

J Sainz, M Sata - Arteriosclerosis, thrombosis, and vascular biology, 2006 - Am Heart Assoc
The accumulation of smooth muscle cells (SMCs) plays a principal role in the pathogenesis
of various vascular diseases. It has been hypothesized that dedifferentiated SMCs migrate …