Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder
manifested by cognitive, memory deterioration and variety of neuropsychiatric symptoms …
manifested by cognitive, memory deterioration and variety of neuropsychiatric symptoms …
Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …
[HTML][HTML] Formulation and optimization of coated PLGA–Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting …
GVP Christoper, CV Raghavan, K Siddharth… - Saudi Pharmaceutical …, 2014 - Elsevier
In the current study zidovudine loaded PLGA nanoparticles were prepared, coated and
further investigated for its effectiveness in brain targeting. IR and DSC studies were …
further investigated for its effectiveness in brain targeting. IR and DSC studies were …
Preparation and evaluation of pralidoxime‐loaded PLGA nanoparticles as potential carriers of the drug across the blood brain barrier
W Chigumira, P Maposa, LL Gadaga… - Journal of …, 2015 - Wiley Online Library
Pralidoxime is an organophosphate antidote with poor central nervous system distribution
due to a high polarity. In the present study, pralidoxime‐loaded poly (lactic‐co‐glycolic acid) …
due to a high polarity. In the present study, pralidoxime‐loaded poly (lactic‐co‐glycolic acid) …
Solid lipid nanoparticles for nose to brain delivery of donepezil: formulation, optimization by Box–Behnken design, in vitro and in vivo evaluation
This study was aimed at preparing and characterizing solid lipid nanoparticles (SLNs) of
donepezil (DPL) for delivery to brain via nasal route. SLNs were prepared by solvent …
donepezil (DPL) for delivery to brain via nasal route. SLNs were prepared by solvent …
Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies
Olanzapine (OZ) is a second-generation or atypical antipsychotic which selectively binds to
central dopamine D2 and serotonin (5-HT2c) receptors. It has poor bioavailability due to …
central dopamine D2 and serotonin (5-HT2c) receptors. It has poor bioavailability due to …
In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease
The purpose of this work is to prepare donepezil microparticles (DM) and evaluate its
advantage as a sustained release delivery system with subcutaneous injection once a …
advantage as a sustained release delivery system with subcutaneous injection once a …
[HTML][HTML] Sustained release donepezil loaded PLGA microspheres for injection: preparation, in vitro and in vivo study
W Guo, P Quan, L Fang, D Cun, M Yang - asian journal of pharmaceutical …, 2015 - Elsevier
The purpose of this study was to develop a PLGA microspheres-based donepezil (DP)
formulation which was expected to sustain release of DP for one week with high …
formulation which was expected to sustain release of DP for one week with high …
Surface-coated PLA nanoparticles loaded with temozolomide for improved brain deposition and potential treatment of gliomas: development, characterization and in …
D Jain, A Bajaj, R Athawale, S Shrikhande, PN Goel… - Drug …, 2016 - Taylor & Francis
Hydrophobicity of PLA nanoparticles makes them a good substrate for macrophageal and
reticulo-endothelial system uptake. Long-circulating properties can be imparted to these …
reticulo-endothelial system uptake. Long-circulating properties can be imparted to these …
In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery
Parkinson's disease (PD) is a neurodegenerative disease which is characterized by the loss
of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD …
of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD …