IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?
A Camporeale, V Poli - Frontiers in bioscience, 2012 - iris.unito.it
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the cross talk
between haematopoietic/immune cells and stromal cells, including the onset and resolution …
between haematopoietic/immune cells and stromal cells, including the onset and resolution …
IL-6: a cytokine at the crossroads of autoimmunity
BE Jones, MD Maerz, JH Buckner - Current opinion in immunology, 2018 - Elsevier
Highlights•IL-6 promotes development of Th17 and Tfh cells and suppresses induction of
Treg.•IL-6 signals via three distinct mechanisms: classical, trans signaling and cluster …
Treg.•IL-6 signals via three distinct mechanisms: classical, trans signaling and cluster …
Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4
WT Watford, BD Hissong, JH Bream… - Immunological …, 2004 - Wiley Online Library
Produced in response to a variety of pathogenic organisms, interleukin (IL)‐12 and IL‐23
are key immunoregulatory cytokines that coordinate innate and adaptive immune …
are key immunoregulatory cytokines that coordinate innate and adaptive immune …
IL‐22 and inflammation: Leukin'through a glass onion
LA Zenewicz, RA Flavell - European journal of immunology, 2008 - Wiley Online Library
IL‐22 is a Th17 T‐cell‐associated cytokine that is highly expressed during chronic
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons?
H Mühl - Frontiers in immunology, 2013 - frontiersin.org
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share
characteristic properties such as defined structural features, usage of IL-10R2 as one …
characteristic properties such as defined structural features, usage of IL-10R2 as one …
[HTML][HTML] IL-23-IL-17 immune axis: discovery, mechanistic understanding, and clinical testing
With the discovery of Th17 cells, the past decade has witnessed a major revision of the T
helper subset paradigm and significant progress has been made deciphering the molecular …
helper subset paradigm and significant progress has been made deciphering the molecular …
IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
S Zhu, Y Qian - Clinical science, 2012 - portlandpress.com
IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …
host defence against bacterial and fungal infections, as well as in the pathogenesis of …
Interleukin‐23: as a drug target for autoimmune inflammatory diseases
Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …
Understanding the IL-23–IL-17 immune pathway
BS McKenzie, RA Kastelein, DJ Cua - Trends in immunology, 2006 - cell.com
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …
structural relationship that includes a shared p40 subunit, this does not translate into …
IL‐17 and IL‐22 in immunity: Driving protection and pathology
K Eyerich, V Dimartino, A Cavani - European journal of …, 2017 - Wiley Online Library
IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …