Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the cross talk
between haematopoietic/immune cells and stromal cells, including the onset and resolution …

Highlights•IL-6 promotes development of Th17 and Tfh cells and suppresses induction of
Treg.•IL-6 signals via three distinct mechanisms: classical, trans signaling and cluster …

Produced in response to a variety of pathogenic organisms, interleukin (IL)‐12 and IL‐23
are key immunoregulatory cytokines that coordinate innate and adaptive immune …

IL‐22 is a Th17 T‐cell‐associated cytokine that is highly expressed during chronic
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …

Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share
characteristic properties such as defined structural features, usage of IL-10R2 as one …

With the discovery of Th17 cells, the past decade has witnessed a major revision of the T
helper subset paradigm and significant progress has been made deciphering the molecular …

IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …

Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …