IL-13 is a central mediator of airway hyperresponsiveness and mucus expression, both
hallmarks of asthma. IL-13 is found in the sputum of patients with asthma; therefore, IL-13 is …

BACKGROUND: IL-13 is a central mediator of airway responsiveness and mucus
expression in patients with allergic airway inflammation, and IL-13 is currently a therapeutic …

The Th2 cytokine IL-13 regulates several aspects of the asthmatic phenotype, including
airway inflammation, airway hyperresponsiveness, and mucus production. The Th17 …

Background Increased IL-17A production has been associated with more severe asthma;
however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in …

BACKGROUND: IL-17A and IL-19 are highly expressed in chronic inflammatory diseases,
such as psoriasis and asthma. IL-19 plays a significant role in the enhancement of TH2 …

Abstract IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an
influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in …

Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic
inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction …

IL-17A is produced from Th17 cells, and is involved in many autoimmune and inflammatory
diseases. IL-13R has not previously been reported to be functionally expressed on T cells; …

IL‐23‐and IL‐17A‐producing CD4+ T cell (Th17 cell) axis plays a crucial role in the
development of chronic inflammatory diseases. In addition, it has been demonstrated that …

IL-15 is an important IL-2–related cytokine whose role in Th17 cell biology has not been fully
elucidated. In this study, we show that exogenous IL-15 decreased IL-17A production in …