Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B‐precursor acute lymphoblastic leukemia
DC Liang, SH Chen, HC Liu, CP Yang… - Pediatric Blood & …, 2018 - Wiley Online Library
Background We aimed to investigate the frequencies and the association with
genetic/cytogenetic abnormalities as well as prognostic relevance of RAS pathway …
genetic/cytogenetic abnormalities as well as prognostic relevance of RAS pathway …
[HTML][HTML] Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
A Agraz-Doblas, C Bueno, R Bashford-Rogers… - …, 2019 - ncbi.nlm.nih.gov
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study
ML Den Boer, M van Slegtenhorst… - The lancet …, 2009 - thelancet.com
Background Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to
determine risk and treatment in children. 25% of precursor B-ALL cases are genetically …
determine risk and treatment in children. 25% of precursor B-ALL cases are genetically …
Childhood B-acute lymphoblastic leukemia: a genetic update
JS Woo, MO Alberti, CA Tirado - Experimental hematology & oncology, 2014 - Springer
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …
childhood hematological malignancy, as well as the leading cause of childhood cancer …
Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
[HTML][HTML] Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable
heterogeneity in initial diagnosis, with multiple (sub) clones harboring lesions in relapse …
heterogeneity in initial diagnosis, with multiple (sub) clones harboring lesions in relapse …
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition
For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is
poor, and there is a need for novel therapies to improve outcome. We screened samples …
poor, and there is a need for novel therapies to improve outcome. We screened samples …
Genomic profiling of B-progenitor acute lymphoblastic leukemia
CG Mullighan - Best practice & research Clinical haematology, 2011 - Elsevier
Childhood acute lymphoblastic leukemia (ALL) is comprised of multiple subtypes defined by
recurring chromosomal alterations that are important events in leukemogenesis and are …
recurring chromosomal alterations that are important events in leukemogenesis and are …
Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 …
V Conter, CR Bartram, MG Valsecchi… - Blood, The Journal …, 2010 - ashpublications.org
Abstract The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-
Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the …
Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the …
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 …
E Clappier, MF Auclerc, J Rapion, M Bakkus, A Caye… - Leukemia, 2014 - nature.com
Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
are used for risk stratification. However, a significant number of BCP-ALL patients are still …
are used for risk stratification. However, a significant number of BCP-ALL patients are still …